abstract：BACKGROUND:Metastasis of malignant breast cells is in part mediated through degradation of the extra-cellular matrix by proteolysis, enabling malignant cells to migrate through the surrounding stroma. Heparanase-1 (HPR1) is an endoglycosidase that specifically degrades the heparan sulfate (HS) moiety of proteoglycans, ...

journal_title：Surgery

authors： Maxhimer JB,Quiros RM,Stewart R,Dowlatshahi K,Gattuso P,Fan M,Prinz RA,Xu X

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Isolated limb perfusion (ILP) with melphalan is an accepted treatment for intransit melanoma of the extremities. Using an ILP human melanoma xenograft model, we tested the hypothesis that acidosis augments the antitumor effect of melphalan and that nitric oxide (NO) induction mediates tumor regression. METH...

journal_title：Surgery

authors： Kelley ST,Menon C,Buerk DG,Bauer TW,Fraker DL

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Plasma from laparotomized mice has been shown to stimulate in vitro tumor growth when compared to results with preoperative plasma. This study assessed the effect of plasma from patients who underwent major open (OS) or laparoscopic surgery (LS) on in vitro tumor cell growth. METHODS:Eighty-four patients un...

journal_title：Surgery

authors： Kirman I,Cekic V,Poltaratskaia N,Asi Z,Bessler M,Huang EH,Forde KA,Whelan RL

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to clarify the still poorly understood dynamics of peritoneal inflammatory cells (PICs) in acute pancreatitis. METHODS:Acute pancreatitis of 3 different degrees of severity was induced in male Wistar rats. Peritoneal lavage was performed at 1, 6, 12, and 24 hours after the indu...

journal_title：Surgery

authors： Mikami Y,Takeda K,Shibuya K,Qiu-Feng H,Egawa S,Sunamura M,Matsuno S

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Major hepatic resection in patients with unrelieved obstructive jaundice carries an increased risk of postoperative liver failure. We hypothesized that cholestasis induces hepatocyte apoptosis and impairs hepatic regeneration by inhibiting up-regulation of the known immediate-early response genes, nuclear fa...

journal_title：Surgery

authors： Bird MA,Lange PA,Schrum LW,Grisham JW,Rippe RA,Behrns KE

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:The diagnosis of acute abdominal conditions in the critically ill patient remains difficult. The goal of this study is to demonstrate the use of bedside minilaparoscopy as a diagnostic aid in the intensive care unit (ICU) in patients with possible intra-abdominal catastrophic condition. METHODS:Between Febr...

journal_title：Surgery

authors： Gagné DJ,Malay MB,Hogle NJ,Fowler DL

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Classic surgical treatment of upper third gastric carcinoma is based on an extended total gastrectomy, including splenectomy. The purpose of this study was to perform a prospective randomized clinical trial comparing the early and late results of total gastrectomy (TG) versus total gastrectomy plus splenecto...

journal_title：Surgery

authors： Csendes A,Burdiles P,Rojas J,Braghetto I,Diaz JC,Maluenda F

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND:From a post hoc analysis a hypothesis was generated that women deposit more collagen in a surrogate test wound than men. The purpose of this study has been to verify this hypothesis prospectively in a controlled study. METHODS:Post hoc analyses were done on 37 volunteers (study A). The prospective trial inc...

journal_title：Surgery

authors： Jorgensen LN,Sorensen LT,Kallehave F,Vange J,Gottrup F

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Misdiagnosed primary hyperparathyroidism (PHPT) during thyroid surgery may lead to a difficult reoperation. Because PHPT is often asymptomatic, calcium measurements have been recommended before thyroid surgery, but no study has focused on the results of a prospective PHPT screening. METHODS:The prospective ...

journal_title：Surgery

authors： Denizot A,Dadoun F,Meyer-Dutour A,Alliot P,Argème M

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:The number of dendritic cells (DC) in the local tumor environment correlates with patient survival in numerous tumors. The relationship of DC infiltration in the tumor microenvironment and prognosis was examined in patients with pancreatic adenocarcinoma. METHODS:Forty-seven pancreatectomy specimens with a ...

journal_title：Surgery

authors： Dallal RM,Christakos P,Lee K,Egawa S,Son YI,Lotze MT

更新日期：2002-02-01 00:00:00

abstract：BACKGROUND:Clinical parameters influencing the effect of preoperative portal vein embolization (PVE) in hypertrophying the nonembolized lobe of patients with either normal or abnormal liver parenchyma and its effect upon portal pressure were examined to identify the patient population for whom this approach is most sui...

journal_title：Surgery

authors： Wakabayashi H,Ishimura K,Okano K,Karasawa Y,Goda F,Maeba T,Maeta H

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:A new concept of surgical stress has been proposed that consists of both aggressiveness of operation and systemic reactions to an operation. METHODS AND RESULTS:We have investigated a possible modulation of such systemic reactions to operation and have demonstrated the following 3 points: (1) coagulation an...

journal_title：Surgery

authors： Shimada M,Harimoto N,Maehara S,Tsujita E,Rikimaru T,Yamashita Y,Tanaka S,Shirabe K

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Late graft failure is still a problem for vascular surgeons. A previous study showed superior patency of arterial grafts compared with venous grafts. In this review we discuss the differences in functional and morphologic modulation of experimental autogenous venous and arterial grafts. RESULTS:In canine ve...

journal_title：Surgery

authors： Komori K,Inoguchi H,Kume M,Shoji T,Furuyama T

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Living-donor liver transplantation has become a legitimate alternative to cadaveric liver transplantation. However, information on the perioperative management of donors is still scarce. METHODS:Between October 1996 and May 2001, 52 consecutive living-donor liver transplantations have been performed at the ...

journal_title：Surgery

authors： Soejima Y,Harada N,Shimada M,Suehiro T,Minagawa R,Hiroshige S,Ninomiya M,Shiotani S,Nishizaki T

更新日期：2002-01-01 00:00:00

abstract：:Solid tumors constantly require a vascular supply for their progression and metastasis. Hepatocellular carcinoma (HCC) is known to gain its hypervascularity during the process of dedifferentiation and progression. Various angiogenic growth factors and inhibitors regulate this angiogenic switch of HCC. The known endoth...

journal_title：Surgery

authors： Sugimachi K,Tanaka S,Terashi T,Taguchi K,Rikimaru T,Sugimachi K

更新日期：2002-01-01 00:00:00

abstract：:This review concentrates on the clinicopathologic studies and molecular biologic studies of intramucosal gastric carcinomas (IMGCs) with lymph node metastasis that have been published to date. There have been several reports in which IMGCs with lymph node metastasis were compared with IMGCs without lymph node metastas...

journal_title：Surgery

authors： Kabashima A,Maehara Y,Koga T,Kakeji Y,Sugimachi K

更新日期：2002-01-01 00:00:00

abstract：:The multiple occurrence of squamous cell carcinoma is frequent in the upper aerodigestive tract (UADT). Risk factors not only for esophageal cancer, but also for multiple cancer in the UADT, were reviewed. Both cigarettes smoking and alcohol drinking are will known risk factors for esophageal cancer. The joint effect ...

journal_title：Surgery

authors： Morita M,Saeki H,Mori M,Kuwano H,Sugimachi K

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that low computed tomography (CT) attenuation values can be used to differentiate benign adrenal adenomas from non-adenomas. We examined the utility of non-enhanced CT attenuation values of

journal_title：Surgery

authors： Nwariaku FE,Champine J,Kim LT,Burkey S,O'keefe G,Snyder WH 3rd

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:We hypothesized that intraoperative parathyroid hormone monitoring (IOPTH) reliably would detect double parathyroid adenomas. METHODS:This was a retrospective study of 20 patients undergoing conventional parathyroidectomy with resection of exactly 2 abnormal glands. Full exploration was performed regardless...

journal_title：Surgery

authors： Gauger PG,Agarwal G,England BG,Delbridge LW,Matz KA,Wilkinson M,Robinson BG,Thompson NW

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that mitogen-activated protein (MAP) kinase contributes to the growth and tumorigenesis of human epithelial cancers. Furthermore, blockade of this pathway may inhibit the growth of epithelial cancers. To determine whether MAP kinase is activated in human papillary thyroid carcinomas (P...

journal_title：Surgery

authors： Specht MC,Barden CB,Fahey TJ 3rd

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:Activated factor X (FXa) is involved in hemostasis, thrombogenesis, inflammation, and cellular immune response. Tissue factor (TF) is an initiator of blood coagulation. We investigated whether FXa induces TF expression in human peripheral monocytes and whether treatment with FXa inhibitor reduces TF expressi...

journal_title：Surgery

authors： Akahane K,Okamoto K,Kikuchi M,Todoroki H,Higure A,Ohuchida T,Kitahara K,Takeda S,Itoh H,Ohsato K

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:The purpose of this study is to detail the use of advanced tissue transfer techniques to achieve primary closure of the perineal wound after proctectomy for Crohn's disease. METHODS:Between October 1984 and March 2000, we performed proctectomy with permanent intestinal stoma in 97 patients with Crohn's dise...

journal_title：Surgery

authors： Hurst RD,Gottlieb LJ,Crucitti P,Melis M,Rubin M,Michelassi F

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Surgical success has traditionally been judged from the surgeon's perspective. A more complete evaluation of outcome incorporates the patient's, surgeon's, and payor's perspectives. Because gastroesophageal reflux disease (GERD) is primarily a quality-of-life (QOL) problem, the evaluation of laparoscopic fun...

journal_title：Surgery

authors： Feldman LS,Mayrand S,Stanbridge D,Mercier L,Barkun JS,Fried GM

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Nosocomial pneumonia (NP) in injured patients is a significant clinical problem. We hypothesize that the pathogenesis of NP in injured patients involves an imbalanced cytokine response within the alveolar airspace that may inhibit effector cell function. METHODS:Proinflammatory (IL-8) and anti-inflammatory ...

journal_title：Surgery

authors： Muehlstedt SG,Richardson CJ,West MA,Lyte M,Rodriguez JL

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Long-term follow-up of heart, liver, and lung transplantation has led to an increased recognition of secondary end-stage renal failure (ESRF) in transplant recipients. This study examines our center's experience with renal transplantation following previous solid organ transplantation. METHODS:From January ...

journal_title：Surgery

authors： Coopersmith CM,Brennan DC,Miller B,Wang C,Hmiel P,Shenoy S,Ramachandran V,Jendrisak MD,Ceriotti CS,Mohanakumar T,Lowell JA

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:The "July phenomenon," a common belief in medical academia, refers to purported errors, inefficiency, and negative outcomes during the summertime transition of the house staff. We hypothesized that care in a trauma service is consistent throughout the year and that the July phenomenon therefore is a myth. M...

journal_title：Surgery

authors： Claridge JA,Schulman AM,Sawyer RG,Ghezel-Ayagh A,Young JS

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Statewide trauma systems are implemented by health care policy makers whose intent is to improve the process of care delivered to seriously injured patients. In Oregon, Advanced Trauma Life Support (ATLS) training was mandated for all physicians employed in the emergency department of trauma centers. The pur...

journal_title：Surgery

authors： Olson CJ,Arthur M,Mullins RJ,Rowland D,Hedges JR,Mann NC

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Apolipoprotein J (ApoJ) is expressed after vascular injury and remodeling and may inhibit endothelial cell activation in the vascular wall. Recently, ApoJ was identified as upregulated in hyperplastic lesions after prosthetic arterial grafting. This study analyzed the effect of ApoJ on human umbilical vein e...

journal_title：Surgery

authors： Sivamurthy N,Stone DH,LoGerfo FW,Quist WC

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Case-control studies have reported an inverse relationship between appendectomy and the risk of ulcerative colitis, but the association has not been confirmed in prospective studies. METHODS:Using national hospital discharge registry data in Denmark, the authors followed up 154,434 patients who underwent ap...

journal_title：Surgery

authors： Frisch M,Johansen C,Mellemkjaer L,Engels EA,Gridley G,Biggar RJ,Olsen JH

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND AND AIMS:The optimal protocol of the treatment for early gastric cancer has not been fully established. The current study was designed to elucidate the relationship between the depth of tumors with or without an ulcer and the presence of lymph node metastasis and to establish the optimal and practical therap...

journal_title：Surgery

authors： Shimada S,Yagi Y,Shiomori K,Honmyo U,Hayashi N,Matsuo A,Marutsuka T,Ogawa M

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:A redundant publication is one which duplicates previous, simultaneous, or future publications by the same author or group or, alternatively, could have been combined with the latter into one paper. As there is no information about the extent of this problem in the surgical literature, we set out to assess t...

journal_title：Surgery

authors： Schein M,Paladugu R

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Muscle protein catabolism, reflected by a decrease in glutamine (GLN), a decrease in muscle protein synthesis, and a negative nitrogen balance can be reduced by either administration of GLN or growth hormone (GH). In this study, the effects of a combination of GH and GLH were studied. METHODS:Patients (n = ...

journal_title：Surgery

authors： Hammarqvist F,Sandgren A,Andersson K,Essén P,McNurlan MA,Garlick PJ,Wernerman J

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Extrinsic denervation of the transplanted small bowel could play a substantial role in motor dysfunction of the transplanted gut. We attempted to determine the effect of chronic extrinsic denervation on intestinal contractility. METHODS:Jejunal longitudinal muscle strips were obtained from rats 1 week and 8...

journal_title：Surgery

authors： Balsiger BM,Ohtani N,Anding WJ,Duenes JA,Sarr MG

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:The effect of the time interval between colorectal and liver resection for metastatic lesions on the patient's survival remains controversial. Pretreatment classification for predicting the prognosis of this disease has not yet been reported. METHODS:Nine clinical factors revealed by preoperative examinatio...

journal_title：Surgery

authors： Sugawara Y,Yamamoto J,Yamasaki S,Shimada K,Kosuge T,Makuuchi M

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:Parathyroid autotransplantation (PTHAT) during thyroidectomy has been shown to reduce the incidence of permanent hypoparathyroidism. Although selective PTHAT is most commonly adopted, the value of routine PTHAT has not been well documented. METHODS:From January, 1998 to March, 1999, an operative strategy in...

journal_title：Surgery

authors： Lo CY,Lam KY

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:The heterogeneous nature of carcinoid tumors makes it difficult to develop a standardized treatment strategy for the primary tumor itself and for probable liver metastases. However, prolongation of the 5-year survival rate (5-ysr) and amelioration of the incapacitating symptoms after resection of the primary...

journal_title：Surgery

authors： Nave H,Mössinger E,Feist H,Lang H,Raab H

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:The incidence of adenocarcinoma of the esophagogastric junction is rapidly increasing, and the extent of lymphadenectomy for such tumors remains controversial. The aim of this study was to identify the pattern of dissemination by examination of all lymph nodes retrieved from resected tumors of the esophagoga...

journal_title：Surgery

authors： Dresner SM,Lamb PJ,Bennett MK,Hayes N,Griffin SM

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Controversy exists about the routes of invasion (extrathyroidal versus lymphogenic extension) when differentiated carcinoma (DTC) and medullary thyroid carcinoma (MTC) invade the cervicovisceral axis (ie, larynx, trachea, esophagus). METHODS:We carried out an institutional analysis, from November 1994 to Oc...

journal_title：Surgery

authors： Machens A,Hinze R,Lautenschläger C,Thomusch O,Dralle H

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Endoscopic endocrine neck surgery requires insufflation with carbon dioxide (CO(2)) at 10 to 15 mm Hg, which may decrease the cerebral venous return and increase intracranial pressure. This study evaluated the effect of CO(2) neck insufflation on intracranial pressure (ICP) and hemodynamic parameters. METHO...

journal_title：Surgery

authors： Rubino F,Pamoukian VN,Zhu JF,Deutsch H,Inabnet WB,Gagner M

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:The management of pancreaticoduodenal endocrine tumors (PETs) remains controversial in multiple endocrine neoplasia type 1 (MEN 1). METHODS:Twenty-one patients with MEN 1 and PETs were analyzed for outcome of surgery and surveillance with special regard to the genotype based on MEN1 gene mutation analysis. ...

journal_title：Surgery

authors： Bartsch DK,Langer P,Wild A,Schilling T,Celik I,Rothmund M,Nies C

更新日期：2000-12-01 00:00:00